- Robin Berzin MD
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- Is Sleep Consistency the Most Overlooked Measure of Longevity?
Is Sleep Consistency the Most Overlooked Measure of Longevity?
Plus, The 30-30 Rule I'm committing to this season.

Poor sleep is linked to over 170 health conditions.
Honestly, I’ve always been a little irritated by the sleep-preaching crowd. It’s not that I doubt the science linking sleep to longevity—I just haven’t been great at prioritizing it.
I’m a “sleep-when-I’m-dead” kind of woman.
But this month I read a fascinating study in Nature about one of the reasons why sleep is so strongly linked to longevity: when you don’t get enough sleep—either in quantity or quality—your mitochondria begin to fragment and accumulate damage. That damage can drive a cascade of dysfunction and disease.
My sleep schedule is all over the place, but it didn’t seem like it was doing me much harm.
Because I live the Parsley lifestyle, at 44, my metabolic health is strong, my chronic disease risk is low, and my labs still look like they belong to someone in her 30s.
Then I ran my WHOOP biological age test.
After 30 days of data collection, WHOOP pegged my biological age at two years older than my actual age. WTF.
Along with not doing enough cardio, the biggest contributor to my advanced biological age? Sleep inconsistency. Time to start paying attention.
⚡️ Forward this protocol
Here’s the sleep hack no one talks about:
If your bedtime swings more than 60 minutes, you age faster. Period.
Even a one-hour swing in sleep timing spikes next-day inflammation and raises your metabolic risk factors (Diabetes Care, 2019).
The fix is ridiculously simple: The 30–30 Rule.
Keep your bedtime within 30 minutes
Keep your wake time within 30 minutes
Even if you get less sleep overall this season, prioritizing The 30-30 Rule will:
Lower cortisol
Improve metabolic flexibility
Support a younger biological age
🤓 What to know: Sleep consistency is more important than duration for inflammation and metabolic health.
Most sleep advice focuses on how much you sleep. That’s important—but for women trying to improve metabolic health and reduce inflammation, when you sleep may matter more.
⏰ Inconsistent sleep confuses your circadian clock
Your circadian rhythm is regulated by a master clock in the brain—the suprachiasmatic nucleus—but it relies on regular sleep and wake cues to stay synced. When those cues shift night to night, your downstream clocks (in the liver, pancreas, gut, and heart) fall out of rhythm.
That can lead to:
Metabolic instability
Mood swings
Decreased immune function
🔥 Irregular sleep timing increases inflammation
Studies show that just a few nights of inconsistent sleep can elevate next-day inflammatory markers like IL-6 and CRP—especially in women (Frontiers in Neurology, 2020).
📉 Sleep inconsistency worsens metabolic health
Late or irregular bedtimes shift your cortisol and melatonin secretion curves, which reduces next-day insulin sensitivity by up to 25% (Diabetes, Obesity and Metabolism, 2018).
Even when they’re getting enough sleep, people with irregular sleep schedules have significantly higher odds of metabolic abnormalities (Diabetes Care, 2019) including:
High fasting glucose
High triglycerides
Low HDL
Elevated waist circumference
💓 Inconsistent sleep blunts your cardio fitness response
Sleep inconsistency raises baseline sympathetic tone (Frontiers in Neurology, 2025), meaning your body may have a harder time recovering from stress or workouts.
😴 Sleep duration still matters—but differently
For next-day inflammation and metabolic stability, sleep consistency is the lever most women overlook (and the one that has the fastest impact).
But for optimal longevity, you need all three levers—consistency, quality, and duration—working together.
Think of it this way:
Consistency = metabolic stability
Duration = long-term cognitive and cardiovascular disease risk
💪 What to do: Build the three sleep habits that matter most for longevity.
⏰ Step 1: Lock in your sleep window.
This is the fastest lever to pull if you want to improve next-day metabolic function.
Bedtime: Stay within a 30–60 minute window
Wake time: Stay within 30 minutes
Sleep duration: 7–9 hours (Women often need slightly more due to higher slow-wave sleep needs, menstrual cycle–related recovery demands, and more fragmented sleep in perimenopause/menopause.)
😴 Step 2: Optimize sleep quality (Deep + REM)
Deep (slow wave) sleep handles physical repair and glucose regulation; REM handles emotional regulation and memory consolidation.
If you’re tracking via a wearable, Deep + REM Sleep should account for 40-50% of your total sleep time.
Simple ways to increase restorative sleep:
Avoid screens 30 min before bed (blue light delays REM).
Cool your room to 60–67°F. (Temp-controlled beds like Eight Sleep help if you run hot.)
Take a warm bath or shower. (Core temp drop helps with sleep onset.)
Block all light with blackout curtains or an eye mask. (Even tiny amounts of light suppress melatonin.)
Nasal breathing via mouth taping a few nights/week reduces night wakings.
🍽️ Step 3: Eat to prevent 3 a.m. wake-ups
Blood sugar crashes are one of the most common reasons women wake between 2–4 a.m.
Dinner: 30–40g protein, 15–25g healthy fats, 20–40g complex carbs (avoid refined carbs/sugar)
Bedtime snack (if needed): 10–15g protein, 8–12g fat, low or no sugar
💊 What about supplements?
✅ Use:
Magnesium glycinate (400 mg): Calms the nervous system, supports deeper sleep. (Especially helpful in the luteal phase.)
⚠️ Use strategically:
Melatonin (1 mg): Best used as a circadian reset tool, not a nightly sleep aid. Ideal for jet lag or short-term disruptions to your schedule.
🚫 Avoid:
Ambien + benzodiazepines: Can disrupt sleep architecture, increase mortality and dependency risk.
Antihistamines (Benadryl, Unisom): Reduce deep sleep, impair next-day cognition.
Alcohol: Blocks REM, raises resting heart rate, and prevents normal core temperature drops.
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💛 The Momgevity Files
One of my best longevity-minded mom friends (who also happens to be a champion skier) likes to say, “There is no such thing as bad weather. Only bad gear.”
I love this saying, and it’s been on my mind this week as we enter the thick of holiday season. It feels like we’re all contending with some collective weather right now.
There’s the emotional weather of family dynamics and expectations. The scheduling weather of kids’ vacations, holiday events, and travel. And then the literal weather—here in New York, the cold wind and gray skies came in fast this year, leaving even the most seasonal-depression-proof among us feeling the chill.
Last year at this time was particularly stressful for me. As we put up the Christmas tree today, I felt a wave of that memory return and, honestly, wanted to run away from these next few weeks. I caught myself wishing I could fast-forward to February, when my family’s Costa Rica trip is in sight, like skipping ahead in a movie.
But instead, I’m facing the weather—and upgrading my gear.
This season, “gear” looks like:
Skipping alcohol wherever possible. It’s too much of a sleep disruptor and mood downer.
Squeezing in workouts even when there’s no time and no desire, because that post-sweat clarity—whether from a pounding heart rate or a deep yoga stretch—is unmatched.
Sauna hangs with friends.
Saying no to some invitations.
A daily gratitude list of ten things I’m thankful for, even on the tough days.
It’s saying yes, like I did last night, to going out dancing—breaking routine just to move and lose myself in music. It’s giving myself space to meditate and actually feel my feelings, so they don’t get stuck and morph into anxiety, digestive issues, or headaches. It’s staying consistent with supplements and skincare, small rituals that feel grounding.
And it’s repeating a daily affirmation: saying “hell yes” to exactly what is. (That one’s courtesy of my friend and coach Biet Simkin—if you’re not following her yet, you should!)
Turns out, even the wildest storm, coldest day, or hardest rain can feel beautiful. If you’ve got the right gear.
Stay strong, stay curious and breathe,
Robin
As always, this newsletter is for informational and educational purposes only and is not intended as medical advice. Always consult your healthcare provider before making any health decisions or changes to your treatment plan.
![]() | 👋 I’m Dr. Robin BerzinI’m a mom, wife, doctor, and CEO in my 40s. My goal is to be healthier than ever – and help you do the same. I’m also the founder of Parsley Health, the nation’s leading functional medicine clinic designed to help you reverse chronic disease and optimize your health. Join Parsley using RBMDCREW to save $100 on your membership. |
