- Robin Berzin MD
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- Forget Weight—Muscle Is the Real Longevity Metric.
Forget Weight—Muscle Is the Real Longevity Metric.
Plus, long vs. short walks and the ideal timing for HRT.

What if the number on your scale is doing more harm than good?
In every longevity conversation I have—whether on stage or in an exam room—someone asks: What’s the one thing I should focus on to live longer?
My answer is always the same: build muscle mass.
We’ve all been trained to chase a lower number on the scale and to measure our health (and for women, too often our worth) by that number. The truth?
Weight is the wrong metric for healthy aging.
What actually predicts how long (and well) you'll live is your body composition—especially lean muscle mass. Adults with low skeletal muscle mass have a 57% higher risk of all-cause mortality (PLOS One, 2023).
Here’s what to know about how muscle mass will protect your future self.
🤓 What to know: Women with >70% lean muscle mass live longer.
Women lose 3-5% of their total muscle mass per decade starting in their 30s.
Building lean muscle mass now will decelerate your trajectory of aging.
Why? Muscle:
🩸Absorbs blood sugar
🔥 Boosts resting metabolic rate
🧬 Increases libido
🦴 Stimulates bone building
🧠 Clears the brain
❤️ Lowers blood pressure
🔥Lowers “inflammaging
🛡️Builds stress resilience
Optimal body composition = 🔼 skeletal muscle + 🔽 visceral fat
Key body composition metrics and optimal ranges:
Lean Mass (total & regional)
Total muscle and other lean tissue (minus fat and bone).
The most important determinant of metabolic health and longevity.
Women over 65 with low muscle mass are 63 times more likely to die early than their stronger counterparts (Journal of Bone and Mineral Research, 2019).
🌟 Optimal range: 70–75% for women; 80–85% for men
Skeletal Muscle Index (SMI):
Total lean muscle mass in your arms and legs ÷ height.
Tells you how muscular you are for your frame.
Lower SMI = higher mortality risk (PLOS One, 2023).
🌟 Optimal range: ≥ 6.5 kg/m² for women; ≥ 8.5 kg/m² for men
Visceral Adipose Tissue (VAT):
Deep fat around organs.
Elevated VAT drives inflammation, insulin resistance, and cardiometabolic disease.
High VAT is independently associated with shorter lifespan, even in people with “normal” BMI (Circulation, 2021).
🌟 Optimal range: <1 lb for women; <2 lbs for men
Android/Gynoid Ratio (A/G):
Indicates fat distribution—whether you store fat around your organs or hips/thighs.
Higher ratio signals higher metabolic and cardiovascular risk.
🌟 Optimal range: < 0.8 for women; < 1.0 for men
📌 Best way to measure all of this?
A full-body DEXA scan. (I wrote about it in detail here.) Ten minutes. ~$100. Totally worth it.
💪 What to do: Lift heavy, time your protein, supplement strategically.
You don’t need to become a bodybuilder. But you do need to train with intention. Here's my muscle-support protocol:
🏋️ 1. Prioritize 20-30 minutes of heavy resistance training.
Lift 60-85% of your one-rep max
Perform 6–12 reps, 3–5 sets per muscle group
Stop 1-2 reps shy of your max effort—you don’t need to train to failure (Journal of Sports Health and Science, 2021)
Train each muscle group 2–3x/week (Sports Medicine, 2016)
⚠️ Pilates and yoga are great for mobility and core strength but not muscle growth. Think of them as supporting tools, not your main strategy.
🥩 2. Pace your protein
Leucine—the key amino acid that triggers muscle protein synthesis—is the metabolic signal that tells your body to build new muscle.
As we age, that signal gets harder to trigger, meaning we need more high-quality protein to hit the threshold.
Target ~0.7 g per lb of ideal body weight daily. Going higher adds little extra benefit (British Journal of Sports Medicine, 2018).
Hit 25–35 g of high-quality protein per meal to reach the leucine trigger point (Frontiers in Nutrition, 2024).
Timing around workouts helps—but total intake matters more
🍞 3. Eat carbs for intense lifting
Carb loading doesn’t have much of an impact on performance and recovery unless you’re lifting 10+ sets per muscle (Nutrients, 2022).
Eat 0.5–1 g carbs per lb of body weight before/after training
Pair with protein to replenish glycogen and support repair
Focus on real foods: oats, sweet potatoes, quinoa, rice
💊 4. Evidence-based supplement support
Creatine monohydrate (3–5 g/day): Boosts strength, lean mass, and may support cognition (Alzheimer’s & Dementia, 2025)
Urolithin A (500–1,000 mg/day): Improves muscle strength and endurance in middle age (Nature Aging, 2022).
Fortetropin® (2.5 g/day): Early evidence on this one, but may boost muscle protein synthesis (PLOS One, 2023)
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⚡️ Quick Hits
⏱️ Longer walks beat shorter ones
A new analysis finds that continuous movement ≥15 minutes lowers heart risk better than racking up the same steps in lots of 5-minutes-or-less spurts—especially if your total step count is under ~8,000 steps/day.
I’m committing to logging at least one 15 minute walk per day with my WHOOP.
💊 Start estrogen earlier
Starting estrogen early—10 years before menopause—may slash the risk of breast cancer, heart attack, and stroke by up to 60%, per new data.
Establish your baseline and track hormone levels with Parsley Longevity Labs.
🌍 Is breast cancer care better abroad?
American women are increasingly denied access to intraoperative radiation therapy (IORT)—a single-dose treatment given during breast-cancer surgery that’s standard in many countries. Experts say the real issue is profit.
Forward this to the women you love. 1 in 8 will face a diagnosis.
💛 The Momgevity Files
Happy Halloween! My love-to-love-slash-love-to-hate holiday is officially over.
I love dressing up. This year I was a rose—the international symbol of love and, conveniently, a great excuse to buy one of those beautiful Mexican Day of the Dead flower crowns. I love the joy my kids get from planning and wearing their costumes. And I love the parties and the sense of anticipation.
What I don’t love: the flood of corn syrup, ultra-processed foods, and red dye I’m constantly trying to shield my kids from—like that bird sheltering her chicks from the rain with outstretched wings in that viral Instagram image. I’m mystified by the commercialization and glorification of hoarding and binge-eating sugar. Watching kids trick-or-treating and stuffing bags with more candy than anyone should eat in a year always leaves me feeling a little sad. And I wrestle with the tension between wanting my kids to participate and have fun, and wanting to protect them from foods that harm their bodies.
This year, I let each kid keep their 15 favorite pieces of candy (which, to me, already felt like a lot), and we put the rest from trick-or-treating back in the bowl to give out to others. My oldest—my most stubborn—resisted. He held on to 27 pieces (giving away 39!!) then snuck off and ate half in his room. I tried logic and support instead of consequences and firmness. Neither worked. He crawled into our bed Friday night complaining of a headache and stomach ache. I think the lesson landed, but he’s learned it before and forgotten. He’s only eight. He’s not ready to make this call on his own. (And for those of you suggesting the Switch Witch—trust me, we got a solid year out of that one. The kids are too smart for it now.)
As a parent who cares deeply about health and nutrition—and someone who’s spent the past 15 years working to make America healthier (long before MAHA had any political affiliation—I’m deeply annoyed by where that’s gone, but that’s a conversation for another day) I think a lot about the cultural forces shaping our relationship to food, starting from a very young age. I am not a go-with-the-flow mom. We make all their breakfasts and lunches, cook dinner most nights, teach our kids how to read food labels, and make sure there’s protein and vegetables on every plate. We try not to label foods as “good” or “bad,” because the research shows that moralizing food can increase disordered eating. We love food, and we celebrate it.
So when the “flow” turns into a full-on tsunami of sugar worship, it’s hard not to feel drenched and defeated.
I know my kids will be fine, even though they had a night of candy overload. That’s not what worries me. I have all the tools to rehab their microbiome. What I do worry about are the messages we’re sending our children—the idea that ultra-processed, high-sugar packaged foods aren’t an occasional indulgence, but the background noise of childhood. That’s the real concern.
I trust that my values will take root. But as a longevity mom, I wish our culture made it easier to raise kids in a way that supports healing and thriving, not just coping and indulging.
In the meantime, like all of us, I’m doing my best. That means communicating with clarity and love. Learning year by year. And trying—always—to celebrate collective joy while protecting our personal wellbeing.
Stay calm, stay curious, and breathe,
Robin
![]() | 👋 I’m Dr. Robin BerzinI’m a mom, wife, doctor, and CEO in my 40s. My goal is to be healthier than ever – and help you do the same. I’m also the founder of Parsley Health, the nation’s leading functional medicine clinic designed to help you reverse chronic disease and optimize your health. Join Parsley using RBMDCREW to save $100 on your membership. |
As always, this newsletter is for informational and educational purposes only and is not intended as medical advice. Always consult your healthcare provider before making any health decisions or changes to your treatment plan.
